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Zapenia 100mg Tablet (Box)
Zapenia is prescribed for:
- Treatment-resistant schizophrenia in patients who do not respond to or cannot tolerate conventional antipsychotics.
- Managing psychosis associated with Parkinson’s disease.
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✅ Description:
Clozapine belongs to the atypical antipsychotic class and has a unique receptor binding profile. It interacts with dopamine receptors (D1, D2, D3, D5) but shows higher selectivity for D4 receptors, which may explain its reduced risk of extrapyramidal side effects. It also blocks adrenergic, cholinergic, histaminergic, and serotonergic receptors, contributing to its broad pharmacologic action.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration of Zapenia 100
For Schizophrenia (Adults 16+):
- Day 1: Start with 12.5 mg once or twice (elderly: 12.5 mg once).
- Day 2: Increase to 25–50 mg/day (elderly: 25–37.5 mg).
Gradually increase by 25–50 mg/day (maximum 25 mg/day in the elderly) over 2–3 weeks up to 300 mg/day in divided doses (larger dose at night).
- Maintenance dose: typically 200–450 mg/day; maximum: 900 mg/day.
For Parkinson’s Disease Psychosis:
- Start with 12.5 mg at bedtime; titrate in 12.5 mg increments up to twice a week.
- Usual dose: 25–37.5 mg at bedtime; maximum: 50 mg/day.
In rare cases, the dose can be increased weekly to a maximum of 100 mg/day.
Use only as directed by a registered physician.
✔️ Overdose Effects of Zapenia 100
Symptoms include:
- Altered consciousness (drowsiness to coma)
- Low blood pressure, fast heart rate
- Respiratory depression, excessive salivation
- Seizures, cardiac issues, aspiration pneumonia
Management:
- Ensure airway and breathing.
- Activated charcoal may help; gastric lavage/emesis is not preferred.
- Supportive care with continuous monitoring.
- Avoid adrenaline, quinidine, and procainamide.
- No specific antidote; dialysis is likely ineffective.
✔️ Side Effects
Common: Drowsiness, dizziness, constipation, hypersalivation, headache, nausea, weight gain
Less common: Heartburn, dry mouth, abdominal discomfort
✔️ Drug Interactions
- Hematologic risk: Use with other myelosuppressants may enhance bone marrow suppression.
- CNS depressants/alcohol: May increase sedation.
- Benzodiazepines/psychotropics: Heighten risk of orthostatic hypotension.
- Protein-bound drugs (e.g., warfarin, digoxin): Risk of displacement and altered plasma levels.
- CYP450 interactions:
- Inhibitors (e.g., fluvoxamine, paroxetine): Lower Zapenia dose required.
- Inducers (e.g., carbamazepine): Avoid co-administration; stopping carbamazepine may raise Zapenia levels.
- Avoid adrenaline due to paradoxical hypotensive effects.
✔️ Zapenia is not recommended in patients with:
- Severe heart disease (e.g., myocarditis)
- Significant renal impairment (creatinine clearance <10 ml/min)
- History of neutropenia, agranulocytosis, or bone marrow disorders
- Paralytic ileus
- Psychoses due to alcohol or toxins
- CNS depression, coma, or epilepsy not under control
- Breastfeeding
✔️ Use in Pregnancy & Lactation
- No well-controlled studies in humans. Animal data do not show harmful fetal effects.
- May be used during pregnancy if needed.
- Clozapine is excreted in breast milk; nursing is not recommended.
✔️ Precautions & Warnings
- Do not discontinue abruptly unless medically required; taper off over 1–2 weeks.
- Monitor for cholinergic rebound (e.g., vomiting, diarrhea) after sudden stop.
- High risk of agranulocytosis:
- Weekly WBC/ANC monitoring for 6 months, then biweekly if stable.
- Continue monitoring for 4 weeks after stopping.
- Caution in the elderly and those with hepatic issues, diabetes, cardiovascular disease, or seizure risk.
- May cause metabolic disturbances (e.g., hyperglycemia, weight gain), sedation, orthostatic hypotension, and cardiomyopathy or myocarditis.
- Avoid in patients with urinary retention, glaucoma, or GI obstruction.
✔️ Storage Conditions
Store below 30°C. Keep away from light and out of children's reach.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
